|
rs4680
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Women who carried at least one "A" allele (AA/AG) for both rs165774 and rs4680 single nucleotide polymorphisms were less likely to report depressive symptoms (compared with women with the GG genotype; p = 0.019 and p = 0.037, respectively), although moderation analysis did not support the hypotheses of an interaction with stressful life events (rs165774: odds ratio [OR] = 1.13, 95% CI 0.87-1.46, p = 0.347; rs4680: OR = 1.15, 95% CI 0.91-1.44, p = 0.238).
|
27347613 |
2016 |
|
rs165774
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Women who carried at least one "A" allele (AA/AG) for both rs165774 and rs4680 single nucleotide polymorphisms were less likely to report depressive symptoms (compared with women with the GG genotype; p = 0.019 and p = 0.037, respectively), although moderation analysis did not support the hypotheses of an interaction with stressful life events (rs165774: odds ratio [OR] = 1.13, 95% CI 0.87-1.46, p = 0.347; rs4680: OR = 1.15, 95% CI 0.91-1.44, p = 0.238).
|
27347613 |
2016 |
|
rs1360780
|
|
|
0.030 |
GeneticVariation |
BEFREE |
While we observed main effects of sex, age, body mass index, smoking, and depression symptoms on FKBP5 methylation levels, only the functional FKBP5 SNP (rs1360780) moderated the dynamic changes following DEX.
|
31122292 |
2019 |
|
rs58682566
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We report one genome-wide significant hit; rs58682566 in the EPG5 gene was associated (p = 3.25E-08) with the mean of the depression symptom in the Discovery sample, without confirmation in the Replication sample.
|
29486404 |
2018 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We modeled the interactive effects of peer victimization with three genetic polymorphisms (on 5-HTTLPR, DRD2 TaqIA, and BDNF Val66Met) on depressive symptoms.
|
24819687 |
2015 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We modeled the interactive effects of peer victimization with three genetic polymorphisms (on 5-HTTLPR, DRD2 TaqIA, and BDNF Val66Met) on depressive symptoms.
|
24819687 |
2015 |
|
rs33388
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We have found three polymorphisms (rs6198, rs6191 and rs33388) to be associated with major depressive disorder (MDD) and the same polymorphisms were associated with the predominance of depressive symptoms in the course of bipolar disorder.
|
21764460 |
2011 |
|
rs6191
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We have found three polymorphisms (rs6198, rs6191 and rs33388) to be associated with major depressive disorder (MDD) and the same polymorphisms were associated with the predominance of depressive symptoms in the course of bipolar disorder.
|
21764460 |
2011 |
|
rs6198
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We have found three polymorphisms (rs6198, rs6191 and rs33388) to be associated with major depressive disorder (MDD) and the same polymorphisms were associated with the predominance of depressive symptoms in the course of bipolar disorder.
|
21764460 |
2011 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that the BDNF rs6265 polymorphism was related to the severity of depressive symptoms, and that this association was independent of neurotransmitter levels.
|
21898033 |
2012 |
|
rs1143643
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs16944 minor (A) allele specifically interacted with childhood adversity increasing depressive and anxiety symptoms, while rs1143643's minor (A) allele showed protective effect against depressive symptoms after recent life stress.
|
26891860 |
2016 |
|
rs228644
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found associations meeting multiple testing criteria for significance between the PER3 intronic SNP rs12137927 and decreased odds of reporting "some depressive symptoms" in the SOF sample (odds ratio [OR]: 0.61, 95% confidence interval [CI]: 0.48-0.78, df=1, Wald χ2=-4.04, p=0.000054) and the meta-analysis (OR: 0.61, CI: 0.48-0.78, z=-4.04, p=0.000054) and between the PER3 intronic SNPs rs228644 (OR: 0.74, CI: 0.63-0.86, z=3.82, p=0.00013) and rs228682 (OR: 0.74, CI: 0.86-0.63, z=3.81, p=0.00014) and decreased odds of reporting "some depressive symptoms" in the meta-analysis compared to endorsing none-few depressive symptoms.
|
25892098 |
2015 |
|
rs228682
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found associations meeting multiple testing criteria for significance between the PER3 intronic SNP rs12137927 and decreased odds of reporting "some depressive symptoms" in the SOF sample (odds ratio [OR]: 0.61, 95% confidence interval [CI]: 0.48-0.78, df=1, Wald χ2=-4.04, p=0.000054) and the meta-analysis (OR: 0.61, CI: 0.48-0.78, z=-4.04, p=0.000054) and between the PER3 intronic SNPs rs228644 (OR: 0.74, CI: 0.63-0.86, z=3.82, p=0.00013) and rs228682 (OR: 0.74, CI: 0.86-0.63, z=3.81, p=0.00014) and decreased odds of reporting "some depressive symptoms" in the meta-analysis compared to endorsing none-few depressive symptoms.
|
25892098 |
2015 |
|
rs12137927
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found associations meeting multiple testing criteria for significance between the PER3 intronic SNP rs12137927 and decreased odds of reporting "some depressive symptoms" in the SOF sample (odds ratio [OR]: 0.61, 95% confidence interval [CI]: 0.48-0.78, df=1, Wald χ2=-4.04, p=0.000054) and the meta-analysis (OR: 0.61, CI: 0.48-0.78, z=-4.04, p=0.000054) and between the PER3 intronic SNPs rs228644 (OR: 0.74, CI: 0.63-0.86, z=3.82, p=0.00013) and rs228682 (OR: 0.74, CI: 0.86-0.63, z=3.81, p=0.00014) and decreased odds of reporting "some depressive symptoms" in the meta-analysis compared to endorsing none-few depressive symptoms.
|
25892098 |
2015 |
|
rs25531
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We found no evidence for an association between variants of 5-HTTLPR and rs25531 alleles, and depressive symptoms in Chinese PD patients.
|
19429111 |
2009 |
|
rs1220000453
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found no association between CNTF null-mutation and BDNF C270T polymorphism to any depressive symptoms after exclusion of demented subjects.
|
16797081 |
2006 |
|
rs4680
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We extended this research by investigating whether the val158met polymorphism was associated with childhood symptoms of depression and anxiety in two independent samples of young children (Ns = 476 and 409).
|
23475824 |
2013 |
|
rs6295
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We examined the valine (Val) to methionine (Met) polymorphism in brain-derived neurotrophic factor (BDNF), serotonin 1A receptor (5HT1a-rs6295) polymorphism, and the serotonin transporter-linked polymorphic region (5HTTLPR) interaction with the rs25531 A to G single nucleotide polymorphism (5HTTLPR-rs25531) as predictors of depressive symptoms.
|
25781924 |
2015 |
|
rs6318
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We conducted a random effects meta-analysis using individual level data to examine whether the Cys23Ser variant-either directly, or conditionally depending on the level of psychosocial stress-was associated with depressive symptoms and body mass index (BMI).
|
30333852 |
2018 |
|
rs4680
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We conclude that the COMT Val158Met polymorphism may influence responses to DM (30 mg/d) by decreasing depressive symptoms in BD patients.
|
27930497 |
2017 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that the BDNF Val66Met polymorphism influenced responses to add-on memantine by decreasing depressive symptoms in patients with BP-II.
|
24103632 |
2014 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that the BDNF Val66Met polymorphism influenced responses to add-on memantine by decreasing depressive symptoms in patients with BP-II.
|
24103632 |
2014 |
|
rs6314
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We compared severity of depression symptoms across the rs6311 and rs6314 genotypes, measured from the children's genomic DNA.
|
24968012 |
2014 |
|
rs25531
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Unlike prior studies of stressful life events, the S' 5HTTLPR-rs25531 variant did not predict higher levels of depressive symptoms; instead, we report an exploratory finding of an epistatic effect between BDNF and 5HTTLPR-rs25531 whereby the compounded effects of two LA alleles and BDNF Met/Met genotype elevate risk of depressive symptoms after hip fracture (p=.006).
|
25781924 |
2015 |
|
rs77960347
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Together, these findings implicate the Asn396Ser variant of LIPG in the pathogenesis of depressive symptoms in the general population.
|
27431295 |
2017 |